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Short Article

Principles of Neuropsychopharmacology

ROBERTS. FELDMAN, JERROLD s MEYER, LINDA F. QUENZER. Principles of Neuropsychopharmacology. Sunderland MA: Sinauer Associates, Inc, 1997 xx + 909 pp 485 fg 65 tbl $6995

This combination subject and discussion of basic and clinical research findings is an of the best source of contemporary information forward the basic neuropharmacology of mix with drugss that influence neural systems and behavior. The authors' goal was to revise a 1984 sentence (Fundamentals of Neuropsychopharmacology) and to existing findings developed from molecular neuropharmacological and brain imaging techniques related to basic and clinical actions of psychotropic unsalable articles The result is a substantially strange work. The authors contribute to this interdisciplinary field by the agency of discussing and critically evaluating behavioral and contemporary neurochemical modes that are used to generate the data that they ready In addition, difficult concepts and controversial issues from the two animal and clinical studies are discussed in a detailed, balanced and stimulating manner that should be understandable to close examiners and attractive to professionals.

The work has four major sections, mostly containing 5-6 chapters. The table of satisfieds is presented in summary form. followed on nine detailed pages indicating each chapter's subsections and their locations. The first section existings basic concepts, including dose-response relationships. pharmacokinetic and pharmacodynamic principles, contemporary techniques and methodologies used to measure neurochemical and behavioral variables, and the basic structural and functional anatomy and physiology of the central and autonomic nervous svstem The nearest section covers the organization, neuropharmacology and interactions of the major amine and peptide neurotransmitters and schemes followed by a section devot to the behavioral biology of the major psychoactive unsalable article classes, including chapters on the opiates, amphetamine and cocaine, nicotine and caffeine, alcohol, sedative-hypnotic and anxiolytic remedys and "mind-altering drugs", including marihuana, phencyclidine and LSD There is a final section of three chapters in succession clinical applications, discussing the etiology, diagnosis, mechanisms and controversies related to the pathophysiology of and the therapeutic strategies and agents used to treat schizophrenia, affective disorders and the pair most common neurodegenerative diseases: Parkinson's Disease and Alzheimer's Disease. There is an 84-page bibliography, reflecting through the whole extent of 4,000 references- many of them fresh journal articles- arranged alphabetically by the agency of first author.

The chapters are organized in a manner that integrates methodology, data, issues and of the present day directions for each topic, while permitting an emphasis forward one or more of these areas for instructional final causes The large number of illustrations are accompanied at structures for over 300 remedys and experimental agents. Each chapter is followed according to a detailed summary, which greatly enhances the reader's ability to organize and integrate material. It is instructive to compare this work with the 1.928-page Psychopharmacology: The Fourth Generation of Progres published in 1995 Despite its more extensive and detailed coverage of the field by the agency of experts in each area by means of the latter work (which could be used as a companion hint source), Principles compares favorably in the evaluative and integrated approach it uses for protected topics. This allows students and researchers to have a "feel" for the not away state of knowledge in an area, as well as about of the limitations of this knowledge in explaining the basis of psychopathology and psychotropic put drugs into mechanisms. Hopefully, future revisions will reflect: (i) additional coverage of areas, similar as the structure and function of aspects of the immune method relevant to areas of mix with drugs abuse (e.g., cocaine abuse treatment) and psychiatric disorders that are awaited to become increasingly important to neuropsychopharmacology: (ii) expansion of the sections onward mindaltering drugs and clinical applications: and (iii) the redirection of emphasis away from topics having mainly historical relevance (eg barbiturate abuse).

Since I find this subject a good source of information in my admit teaching and research activities, I highly commend its use for advanced undergraduate and graduate scholars in pharmacy and for close examiners and professionals in medicine and interdisciplinary neuroscience programs.

Bromfeld Hine University of Puerto Rico