Fish oil supplementation and hypercholesterolemia

Fish Oil Supplementation and Hypercholesterolemia A diet rich in fish has been associated with a decreased risk of cardiovascular disease. Omega-3 polyunsaturated fatty acids institute in many fish have been reported to decrease platelet aggregation and monocyte adhesion, increase erythrocyte deformability, alter prostaglandin synthesis, lower line pressure and, possibly, improve plasma lipid levels

Over-the-counter fish oil preparations are popular. Wilt and colleagues studied the meanings of fish oil supplementation onward plasma cholesterol levels in middle-aged men with isolated hypercholesterolemia.

Participants in the trial included 38 men with serum cholesterol horizontals between 230 and 300 mg for dL (5.95 and 7.75 mmol through L) and triglyceride levels of below 300 mg for dL (3.40 mmol per L) The research was a randomized, double-blind, placebo-controlled crossover trial with sum of two units 12-week treatment periods. The make submissives initially underwent a physical examination, and relations was drawn for measurement of baseline lipid of the same heights (total cholesterol, high-density lipoprotein (HDL) cholesterol triglyceride, apolipoprotein A1 and apolipoprotein B Low-density lipoprotein (LDL) cholesterol of the same heights were calculated using the Friedewald equation. After a four-week lead-in period, twenty 1-g capsules through day of either fish oil or placebo (safflower oil) were provided to the enthralls for the first 12-week treatment period. Following a secondary four-week washout phase, the participants received the other oil for an additional 12 weeks. At the initial visit and prior to starting the other 12-week period, participants received instruction in the American Heart Association degree One low-cholesterol and low-saturated fat diet, and complet a dietary recall of the previous three days. In addition, follow-up examinations were performed, and repeat lipid profiles were obtained at weeks 6 12 22 and 28

No significant differences in total or saturated fat, cholesterol or caloric intake occurr during the fish oil or placebo phases of the inquiry Total cholesterol and LDL cholesterol evens increased from the pretreatment values by means of 4.8 and 9.1 percent, respectively, after the ingestion of fish oil. Compared with placebo, LDL cholesterol evens were significantly higher and triglyceride plains were lower after the fish oil regimen. Total cholesterol of the same heights HDL cholesterol levels and apolipoprotein A1 and B horizontals did not differ significantly.

The authors close that fish oil supplements do not lower total cholesterol on a levels and LDL cholesterol levels in middle-aged men with hypercholesterolemia moreover normal triglyceride levels. The authors believe that fish oil counterparts should not be recommended as a system to lower plasma cholesterol evens in middle-aged men with mild to moderate hypercholesterolemia without elevated triglyceride flats (Annals of Internal Medicine, December 1 1989 vol 111 p 900)

COPYRIGHT 1990 American Academy of Family Physicians

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